In ancient times, St. John’s wort was used as a sedative and to treat malaria. It was also used as a balm for wounds, burns and insect bites. Today it is used to treat nervous conditions such as depression, anxiety, and some sleep disorders. St. John’s wort is one of the most commonly used herbal remedy for depression. It is a prescribed medicine in Germany and Ireland, but is still available over the counter, as an herbal remedy, in many countries, including the United States. Research has shown support for its effects on mild to moderate depression, but, severe depression (especially with suicidal thoughts) should be treated by a physician. This herb is also reported to have a sedative and pain reducing effect. It has been used as a remedy for sciatica and rheumatic pain by some.